Detoxicated's natural ingredients include dihydromyricetin sourced from vine tea and used in Asian medicine for centuries as a cure for hangovers

DHM, Dihydromyrecitin

DHM, Dihydromyrecitin

The all-star ingredient in Detoxicated is dihydromyricetin (DHM), aka ampelopsin. It is a flavonoid found in plants, such as vine tea or moyeam tea, which has been used as a natural hangover cure and hangover prevention in Asia for centuries! DHM helps with hangovers by enhancing the body’s natural ability to degrade acetaldehyde, the alcohol byproduct responsible for most hangover symptoms. In addition, DHM protects the liver by reducing oxidative stress and lowering liver enzyme elevation. In animal models, DHM has been shown to counteract the neurotransmitter changes that results in poor sleep and anxiety following alcohol consumption. 

NAC, N-acetyl Cysteine

NAC, N-acetyl Cysteine

Known as the mother of all antioxidants, N-acetylcysteine is well-known for its detoxification benefits. N-acetylcysteine neutralizes free radicals by replenishing glutathione, an antioxidant naturally found in our bodies. Although levels of glutathione are quickly depleted when metabolizing alcohol, supplementing with NAC can ensure the body has the dietary components critical to proper alcohol metabolism. It's no wonder why NAC is an essential in our hangover supplement!

 

Taurine

Taurine

Taurine is an organic compound that inhibits the production of acetaldehyde in the alternative processes of alcohol metabolism. It also enhances the activity of enzymes that detoxify free radicals. In ethanol-treated animal models, taurine has been shown to protect the liver by normalizing the reduced glutathione and also reducing inflammation in the liver.

Prickly Pear

Prickly Pear

Prickly Pear extract has been found to reduce hangover symptoms likely due to its anti-inflammatory effects. In addition to being an anti-oxidant, prickly pear has also been demonstrated to be effective against congeners found in many types of alcohol. Prickly pear has been shown to be most effective when taken prior to alcohol consumption, which is why it is only included in Detoxicated’s Before formula. Trying to get over a hangover? Prickly pear is your guy!

 

White Willow Extract

White Willow Extract

White willow extract from the bark of the white willow tree is a potent anti-inflammatory used in naturopathic medicine. Studies have shown that high levels of inflammation after alcohol consumption are associated with increased hangover symptoms. White willow extract works similarly to aspirin and can help mitigate hangover symptoms caused by inflammation.

B6, Zinc, Magnesium, Selenium, B3

B6, Zinc, Magnesium, Selenium, B3

Detoxicated also contains vitamin B6, zinc, magnesium, and selenium. These critical vitamins and cofactors are consumed by enzymes involved in alcohol metabolism. Replenishing these elements supports the detoxification processes of the liver. Who wouldn't like to detox while they're drinking? Additionally, vitamin B6 has been shown to decrease hangover symptoms when consumed prior to alcohol consumption. Despise hangovers? These vitamins and cofactors will help!

 


References

Y Shen, et al. Dihydromyrecitin as a Novel Anti-alcohol Intoxication Medication. J Neurosci. 2012

T Hyun, et al. Hovenia Dulcis - An Asian Traditional Herb. Planta Med. 2010

M Ogasawara, et al. Reactivity of Taurine with Aldehydes and Its Physiological Role. Chem Pharm Bull. 1993

G Pushpakiran, et al. Protective Effects of taurine on glutathione and glutathione-dependent enzymes in ethanol-fed rats. Pharmazie. 2004

G Pushpakiran, et al. Taurine Restores Ethanol-induced Depletion of Antioxidants and Attenuates Oxidative Stress in Rat Tissues. Amino Acids. 2004

C-J Lin, et al. Taurine Attenuates Hepatic Inflammation in Chronic Alcohol-fed Rats Through Inhibition of TLR4/MyD88 Signaling. J Med Food. 2015

J Balkan, et al. Taurine Treatment Reduces Hepatic Lipids and Oxidative Stress in Chronically Ethanol-treated Rats. Biol Pharm Bull. 2002

S Devi, et al. Taurine Enhances the Metabolism and Detoxification of Ethanol and Prevents Hepatic Fibrosis in Rats Treated with Iron and Alcohol. Env tox and Pharm . 2009

J Weise, et al. Effect of Optunica Ficus Indca on Symptoms of the Alcohol Hangover. Arch Intern Med. 2004

C Lieber, et al. Alcohol: Its Metabolism and Interaction with Nutrients. Annu Rev Nutr. 2000

D Jian, eta l. Semen Hoveniae Extract Protects Against Acute Alcohol-induced Liver Injury in mice. Pharma Bio. 2009